Tacrolimus (TAC), a fermentation product isolated from Streptomyces, is a macrolide antibiotic and a powerful new immunosuppressor that can inhibit cellular immunity mainly by inhibiting the release of interleukin-2 (IL-2).22 It is usually used to prevent the rejection of kidney and liver transplantation.23 It is found in a study carried out by Mok et al.24 that the combination of TAC and prednisolone is not inferior to mycophenolate mofetil, and can be used for the treatment of active LN. This evidence concerns the gene IL2 and lobular neoplasia.