ERBB2 and breast cancer: ErbB receptor family, also known as the EGF receptor family or I-receptor family, includes epidermal growth factor receptor (EGFR) or ErbB1/Her1, ErbB2/Her2, ErbB3/Her3, and ErbB4/Her4 [11], overexpresses, or mutates in many malignancies particularly in breast cancer, ovarian, and NSCLC.