AKT1 and urinary bladder carcinoma: Regarding bladder cancer, constitutive activation of PI3K/AKT pathway was observed in up to 40% of tumors [38], which pathway combined a serial of external signals to regulate downstream signaling involved in the cell growth, differentiation, angiogenesis, and protein synthesis, ultimately resulting in bladder carcinogenesis, metastatic potential, and therapy resistance [39–43].