Univariate Cox regression analysis revealed that overexpression of SOX11, PPFIA4, SLC41A3, SPC25, PIGU, GAPDH, ZC3H3, TAGLN2, DHX37, MCM8, BRD9, CDC123, CCT3, RRP7A, HM13, SLC25A39, DENR, EIF3B, SEC61A1, LRP4, PPM1G, DEGS1, BAMBI, HSP90AA1, and ZNF207 was associated with a poor prognosis for patients with HCC (Figure S5). The gene discussed is SEC61A1; the disease is hepatocellular carcinoma.