Specifically, the overexpression of BAMBI, BRD9, CCT3, CDC123, DEGS1, DENR, DHX37, EIF3B, GAPDH, HM13, HSP90AA1, IQCA1, LRP4, MCM8, PIGU, PPFIA4, PPM1G, RRP7A, SEC61A1, SLC25A39, SLC41A3, SOX11, SPC25, TAGLN2, ZC3H3, and ZNF207 was significantly associated with a poor prognosis for patients with HCC (Figures 5 and S3). The gene discussed is TAGLN2; the disease is hepatocellular carcinoma.