The risk score was correlated with the B lineage, monocytic lineage, neutrophils, myeloid dendritic cells, T cells, cytotoxic lymphocytes, CD8+ T cells, fibroblasts, M0 macrophages, T cells, resting CD4+ memory T cells, activated CD4+ memory T cells, resting mast cells, M1 macrophages, memory B cells, follicular helper T cells, naïve B cells, resting dendritic cells, eosinophils, neutrophils, resting NK cells, and monocytes, which further indicates that the risk model constructed based on sorafenib-response target genes has an important value in predicting HCC progression. Here, CD8A is linked to hepatocellular carcinoma.