TGFBR1 and ischemic stroke: For instance, Chen et al. identified a double-negative feedback loop: let-7i/TGF-βR1 in ischemic stroke, providing a potential therapeutic target for ischemic stroke [37]; Ma et al. indicated that the deletion of miR-15a/16-1 gene in endothelial cells represses BBB dysfunction after ischemic stroke, suggesting that miR-15a/16-1 mediates BBB dysfunction to alleviate ischemic stroke [38].