PPARGC1A and metabolic dysfunction-associated steatohepatitis: In agreement, Kim et al. also demonstrated that RORαLKO mice are more susceptible to high-fat diet-induced non-alcoholic steatohepatitis (NASH) where RORα exerts a beneficial role in mitochondrial quality control by enhancing oxygen consumption rate and the expression of key genes Bnip3 and PGC-1α (23).