When comparing the hypertensive CKD category with the normotensive CKD category, aminopeptidase M (ANPEP) was significantly overexpressed in uEVs derived from the hypertensive CKD category (Q=0.0033), whereas alpha‐2‐macroglobulin (A2M; Q=0.0044), cauxin (CES5A; Q=0.0012), inter‐alpha‐trypsin inhibitor heavy chain 4 (ITIH4; Q=0.0013) and transferrin (TF; Q=6.65×10−4) were significantly underexpressed (Fig 6). The gene discussed is CES5A; the disease is chronic kidney disease.