Subcutaneous administration of C004019 designed to simultaneously recruit tau and E3-ligase (Vhl) and thus selectively enhance ubiquitination and proteolysis of tau proteins, remarkably attenuated the hyperphosphorylation of p70S6K1 (P = 0.7108) and ULK1 (P = 0.2979) in the AD model mice (Fig. 6f). Here, VHL is linked to Alzheimer disease.