Furthermore, co-expressing TIA1-PRD with tau remarkably attenuated the tau-induced perilysosomal aggregation of mTOR measured by co-immunofluorescence staining with anti-LAMP1 and anti-mTOR antibodies (Fig. 6c), recovered protein synthesis inhibition measured by Western blotting using puromycin antibody (Vec/NC group vs. Tau/NC group, P = 0.0013; Vec/PRD group vs. Tau/PRD group, P = 0.9991, Tau/NC group vs. Tau/PRD group, P = 0.0111, Fig. 6d), and recovered autophagy dysfunction measured by immunofluorescence staining (Fig. 6e). This evidence concerns the gene PEPD and X-linked retinal dysplasia.