MAPT and frontotemporal dementia: In-depth SynGO analysis shows that differentially expressed synaptic proteins in FTD-GRN and FTD-MAPT are localized in presynaptic and postsynaptic compartments, and are implicated in a wide range of functions (see visualization in Additional File 6 and extensive results in Additional File 7), likely reflecting the overall impact of neurodegeneration on the synapse.