Using single-cell transcriptomic sequencing of the primary tumor specimens, a study 12 NSCLC patients treated with immunotherapy combined with EGFR-TKI treatment characterized 15 main cell types (including fibroblasts, endothelial cells, tumor cells, macrophages, T cells, B cells, mast cells, neutrophils, dendritic cells, and ciliated cells). This evidence concerns the gene EGFR and neoplasm.