Rag1−/− mice with adoptively transferred CD8+ T cells had a reduction of deficits in spatial reference memory (F(2, 32) = 7.947, P = 0.0016, Fig. 7K) and spatial working memory (P = 0.0186, Fig. 7L) than Rag1−/− mice with control cell transfer, suggesting that endogenous S-2HG reduction alleviated post-stroke cognitive dysfunction. Here, CD8A is linked to stroke disorder.