HIF1A and Stroke: HIF-1α (F(3, 8) = 45.59, P < 0.0001) and LDHA (F(3, 8) = 33.37, P < 0.0001), known to be important for S-2HG production and accumulation, strikingly increased in perioperative stroke mice compared with stroke-only mice (Fig. 5F, G).