CD8A and Stroke: Notably, greatly increased brain-invading CD8+ T lymphocytes (F(3,24) = 6.398, P < 0.0001) were detected in perioperative stroke mice by the flow analysis of ischemic hemisphere, suggesting that the perioperative stroke led to CD8+ T lymphocytes recruitment to brain parenchyma, which could potentially enhance the neurotoxic effect (Fig. 3C).