To reduce the expression of SRI in chemoresistant cancer cells, we developed novel lipid-coated albumin-PTX nanoparticles for PTX and SRI-siRNA co-delivery (LANP-PTX-siSRI) that inhibited the expression of SRI and enhanced intracellular calcium, leading to the induction of apoptosis and the inhibition of PTX-resistant cancer cell growth. Here, ALB is linked to cancer.