PRDM5 and esophageal squamous cell carcinoma: Through univariate analysis, we found that T stage (HR: 0.573, 95%CI: 0.43–0.764; P < 0.001), N stage (HR: 0.526, 95%CI: 0.401–0.69; P < 0.001), TNM staging (HR: 0.509, 95%CI: 0.388–0.667; P < 0.001), PRDM5 expression level (HR: 2.986, 95%CI: 2.084–4.278; P < 0.001), differentiation degree (HR: 0.724, 95%CI: 0.537–0.976; P = 0.034), nerve infiltration (HR: 0.643, 95%CI: 0.429–0.964; P = 0.0.033), and vascular invasion (HR: 0.497, 95%CI: 0.359–0.688; P < 0.001) were risk factors of ESCC patients.