1 × Anemia + 2 × (cTnI/T elevated) + 1 × [BNP 500 to < 1500 pg/mL (NT-proBNP 2500 to < 7500 pg/mL)] or 2 × [BNP ≥ 1500 (NT-proBNP ≥ 7500) pg/mL] + 3 × (QRS fraction of electrocardiogram < 55%) + 1 × (ACEI/ARB not used). This evidence concerns the gene TNNI3 and anemia (phenotype).