In addition, after identifying differential LRFN1 expression using the median cutoff value, we found that high LRFN1 expression markedly correlated with poor prognosis (P = 4.5E−06) and aggressive progression (P = 0.002) in patients with ccRCC from TCGA cohort (Fig. 3E). The gene discussed is LRFN1; the disease is nonpapillary renal cell carcinoma.