The representative images of three groups (control, LRFN1 overexpression plasmid, LRFN1 plus miR-187-3p mimics) are shown in Fig. 6A. LRFN1 overexpression in A498 cells increased the tumour volume 1.79-fold relative to that of its control and increased the tumour weight 2.16-fold relative to its control (Fig. 6B). This evidence concerns the gene LRFN1 and neoplasm.