To investigate the potential functions of LRFN1 in the progression of ccRCC, we screened and identified the significantly differential expressed genes (DEGs) according to LRFN1 expression, and found the significantly up-regulated genes, including WDR32, TMEM174 and SLC6A19; down-regulated genes, including C1R, C1S, CCL21, C1QL1, KRT19 and SAA1 (Fig. 5A). The gene discussed is C1S; the disease is nonpapillary renal cell carcinoma.