These novel findings allow researchers to clearly elucidate the pathological significance of the high expression of a key disease-related factor miR-187-3p in ccRCC cells, and to explore the molecular mechanism of miR-187-3p that mediates the malignant biological behavior and immune-infiltrating TIME of ccRCC cells through LRFN1. The gene discussed is LRFN1; the disease is nonpapillary renal cell carcinoma.