Of note, our NGS panel has routinely identified HMGA2 translocations with diverse downstream partners e.g., HMGA2::PTPRD, HMGA2::WIF1, and HMGA2::ACTR6 in three recent salivary gland tumors (carcinoma ex pleomorphic adenoma) that characteristically harbor HMGA2 rearrangements. This evidence concerns the gene ACTR6 and carcinoma.