Among the mutated genes there was a preponderance of well-established and common endometrial cancer drivers, such as AKT1, ARID1A, BCOR, FBXW7, KRAS, PIK3CA, PIK3R1, PTEN, and TP53, of note because the cancer gene panel is large/comprehensive and designed for systematic detection of cancer drivers across human malignancies, not just endometrial or gynecologic malignancies. This evidence concerns the gene PIK3R1 and cancer.