EPO and anemia (phenotype): Studies have further shown that in erythropoietin-producing liver tumor cells or organs in mice in hypoxia or with severe anemia, the elevated acetate level requires ACSS2 to bind CBP acetylation to the formation of the CBP-HIF-2α complex, which is recruited to the erythropoietin enhancer while efficiently inducing erythropoietin gene expression.