ACSS2 and hereditary clear cell renal cell carcinoma: Studies have also shown that high expression of ACSS2 is correlated with advanced T stage and lymph node metastasis; blockade of ACSS2 inhibits the growth, migration and invasion of renal cell carcinoma cells possibly by suppressing the PI3K/AKT signaling pathway, while overexpression of ACSS2 enhances these effects [89].