ME1 and nonpapillary renal cell carcinoma: 2-NBDG Uptake Assay was then performed and results showed that ectopic expression of ME1 or treatment with ME1 inhibitor remarkably abrogated circME1 silencing- or overexpression-induced the inhibitory or promotive effects on glucose uptake of ccRCC cells (Supplementary Fig. S4C, D).