Although Sema3A-specific deletion in keratinocytes caused upregulated immune cell infiltration, the unchanged ratio of CD4+/CD8+ T cell number and the ratios of the number of macrophages or DCs in the allergy/control groups indicate that the deletion of Sema3A in keratinocytes would not significantly affect the development of Ni allergy. Here, SEMA3A is linked to allergic disease.