TET1 and malignant colon neoplasm: While TET1 mutation was associated with an increase in total mutational burden in colon cancer and melanoma patients (Fig. 3F,G), the relationship between total mutational burden and survival did not reach statistical significance in this cohort of colorectal cancer patients (Fig. 3H), though it remained a significant prognostic factor in the melanoma cohort (Fig. 3I).