After 72 h, 10 and 30 days of sepsis induction there was an increase in the activity of DNMT (sham 72 h = 0.022 ± 0.004; CLP 72 h = 0.057 ± 0.022; sham 10 days = 0.21 ± 0.006; CLP 10 days = 0.067 ± 0.006; sham 30 days = 0.02 ± 0.004; CLP 30 days = 0.077 ± 0.009) (Fig. 4c). This evidence concerns the gene DNMT1 and Sepsis.