A study by Moraes et al.67 exposed that synaptophysin did not show changes in its levels, however the PSD-95 protein demonstrated significantly reduced levels in the hippocampus of mice 24 h and 3 days after sepsis induction, however 30 days after sepsis the co-location of PSD -95 was established at normal levels. This evidence concerns the gene DLG4 and Sepsis.