As shown in Fig. 5a, Sankey plot analysis connected a total of 25 miRNAs that are known to be regulators of canonical inflammatory genes involved in obesity, such as TNF-α, IL-6, and IL-1β, to the list of L_Ag-associated DEMs and O_Ag-associated DEMs. The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.