IRS1 and neoplasm: Further, statistical correlation conducted to support the findings and the proposed pathway of the current study revealed that TAMC mediators (histamine, VEGF, and TNF-α) are positively correlated with the expression of PI3K, AKT, mTOR, and IRS1, indicating their role in tumor proliferation and survival by the activation of PI3K/AKT/mTOR cue.