APOE and diabetes mellitus: When assessing the atherosclerotic plaque area in ApoE−/− x WT versus ApoE−/− x eNOX5ki/ki mice with and without 20 weeks of diabetes, all diabetic mice showed a significant increase in atherosclerotic plaque area in total, arch, thoracic and abdominal aorta compared to non-diabetic mice, yet there was no difference between diabetic ApoE−/− x WT versus diabetic ApoE−/− x eNOX5ki/ki mice in all areas (Fig. 2).