The prominent role of oscillations in temporal coding and information binding, together with the function of SWRs in memory consolidation36 and the reduced network plasticity associated with high PV-IN activity53, all suggest that cognitive deficits caused by aromatase inhibitors in humans and mice may arise from the impact of local estradiol synthesis on PV-INs. The gene discussed is CYP19A1; the disease is Cognitive impairment.