HIF1A and fibrosis: HIF-1α activation promotes glucose consumption and glycolysis and affects lipid metabolism.70,71 HIF-1α is upregulated in hepatocytes in NAFLD and is also a critical regulator of liver fibrosis in NAFLD.200–202 Csak et al. observed that microRNA (miRNA)-122 regulates HIF-1α in hepatocytes and is correlated with fibrosis in methionine-choline-deficient (MCD) diet-induced steatohepatitis.