HIF1A and hepatocellular carcinoma: A study reveals that dictamnine decreases the protein expression of HIF-1α and slug to promote cell apoptosis.108 Besides, the HIF-1α-BNIP3 (B-cell lymphoma 2 (BCL2) and adenovirus E1B 19 kDa-interacting protein 3) pathway mediates mitochondrial autophagy to inhibit apoptosis and ROS production, exerting a protective effect in acute renal injury.109 In addition to HIF-1α-reduced apoptosis in hepatoma cell HepG2,110 HIF-2α inhibits apoptosis and autophagy of cervical cancer cells under hypoxia.111 Accumulating evidence demonstrated that hypoxia increases apoptosis.