PDK1 and colon adenocarcinoma: On the other hand, the inhibition of PFKFB3 restricts glucose uptake in colon adenocarcinoma cells and induces autophagy.96–98 In acute myeloid leukemia (AML), the interaction of pyruvate dehydrogenase kinase 1 (PDK1) between unc-51-like autophagy-activating kinase 1 (UKL1) determines a regulatory manner in autophagy.