ORAI1 and malignant colon neoplasm: Colon cancer arises from the colonic epithelial cells that line the lumen of the organ and results from a multistep process of colon neoplasia over several years.237 Hypoxia is a typical feature of solid tumors in common and it is related to the progression and metastasis of colon cancer.238–240 For example, the expression of Orai1 is induced by hypoxia in colon cancer, which promotes hypoxia-induced invasion and angiogenesis.241 The correlation between colon cancer and hypoxia is illustrated (Fig. 5).