Kong et al. showed a higher expression of nuclear paraspeckle assembly transcript 1 (NEAT1) in NSCLC tissues and cells than that in normal controls, and NEAT1 knockdown suppresses cell proliferation, migration, and invasion in NSCLC.277 Interestingly, NEAT1 promotes EMT and NSCLC cell metastasis under hypoxia in a HIF-2α-dependent manner.277 Wang et al. demonstrated that lncRNA HIF2PUT was downregulated in NSCLC tissues and cell lines, and its overexpression inhibits NSCLC proliferation and invasion via HIF-2α pathway.278. This evidence concerns the gene EPAS1 and non-small cell lung carcinoma.