CXCR4 and gastric cancer: CTHRC1 upregulated the expression of HIF-1α to increase CXC chemokine receptor 4 (CXCR4) expression, ultimately promoting cell migration and invasion.291 Epigallocatechin gallate (EGCG) induces apoptosis and impedes proliferation in GC SGC7901 cells by downregulating the expression of HIF-1α and VEGF under hypoxia.292 Downregulation of HIF-1α, leading to suppressing the PI3K/AKT pathway and VEGF expression, might inhibit the proliferation, migration, and invasion of GC.293