HIF-1α is overexpressed in pancreatic cancer patients, and it regulates expression of various genes associated with pancreatic cancer.315,316 HIF-1α overexpression induces EMT in an NF-κB signaling pathway-dependent manner.317 Several findings discovered that high expression of HIF-1α significantly enhances the capacity of anti-apoptosis in pancreatic cancer cells.318,319. Here, HIF1A is linked to familial pancreatic carcinoma.