CHD is the most common type of congenital deformity, classified into three types based on hemodynamics: no shunt, left to right shunt, and right to left shunt.405–407 Patients with cyanotic CHD (CCHD) might have a hypoxic response, which leads to abnormalities in endothelial function, vascular remodeling, and thrombosis after emergency surgery.408 Prolyl-4-hydroxylase2 (PHDP2)/HIF-1α pathway is the key regulator under hypoxia. The gene discussed is HIF1A; the disease is coronary artery disorder.