High glucose levels suppress hypoxia-induced stabilization of HIF-1α protein level against degradation in specific cells.167 A series of studies have presented the suppressed stabilization and function of HIF-1α in the kidney, wound, and the heart of animal models of diabetes or diabetes patients.166,168,169 Different cell types decide specific roles of HIF-1α activity and signaling in diabetic kidney diseases. This evidence concerns the gene HIF1A and diabetes mellitus.