HIF-2α is essential in the inflammatory response and the regeneration and proliferation capacity of the intestine following an acute injury, and its chronic activation enhances the proinflammatory response, intestinal injury, and colorectal cancer.252 Franovic et al. showed that suppression of HIF-2α restrains tumorigenesis and the proliferation of genetically diverse human cancer cells in vivo.253 Xue et al. suggested that HIF-2α activation increases tumor progression in colon cancer, whereas the HIF-2α-induced tumor formation is reduced upon low-iron treatment.254. Here, EPAS1 is linked to colorectal cancer.