HIF1A and Familial prostate cancer: Prostate cancer is a major disease in males around the world.328 It is the second most common form of cancer in men, surpassed only by nonmelanoma skin cancer.328 The incidence and mortality of prostate cancer are correlated with the mean age at diagnosis is 66 years.329 Zhong et al. found that expression of HIF-1α increases in human and rat prostate cancer cell lines.330 Hypoxia signaling plays a vital role in the tumorigenesis and progression of prostate cancer.