HIF-1α was upregulated in colon cancer tissues.242 Santoyo-Ramos et al. showed that HIF-1α and HIF-2α are expressed in human colon cancer cells but not in non-malignant cells under normoxic conditions.243 Jeon et al. revealed that protein S-glutathionylation increases the protein level of HIF-1α in hypoxic colon cancer cells.244 Zheng et al. demonstrated that DJ-1 protein facilitates the survival of human colon cancer cells by the increased HIF-1α protein expression by means of PI3K-AKT signaling pathway.245. This evidence concerns the gene EPAS1 and malignant colon neoplasm.