Hypoxia increases the migration and invasion of GC cell line BGC-823 by activating HIF-1α and inhibiting N-myc downregulated gene 2 (NDRG2)-associated signaling pathway.289 Xia et al. demonstrated that hypoxia promotes the release of GC exosome and the expression of miR-301a-3p; then, miR-301a-3p-rich exosomes increase HIF-1α accumulation and promote GC malignancy and metastasis.290 Ding et al. showed that collagen triple helix repeat containing 1 (CTHRC1) overexpression increases cell migration and invasion capacity in GC. The gene discussed is CTHRC1; the disease is gastric cancer.