HIF1A and amyotrophic lateral sclerosis: In an ALS in vivo model, the induction of HIF-1α decreases hypoxia-caused damage, protecting the neurons, reducing the inflammatory response, and lessening motor neuron degeneration.438 Conversely, decreased HIF-1α expression induced by ONO-1301-MS increases motor neuron generation in the mice model of ALS.441 Nonetheless, these findings need to be investigated further with respect to HIF-1α in ALS.