Some studies demonstrated that in the process of duodenal ulcer, ischemia induces HIF-1α expression and angiogenesis factors production including VEGF.526 Clinical trials demonstrated H. pylori eradication for the treatment of H. pylori-associated duodenal ulcers.527 Reportedly, H. pylori infection increases the expression of HIF-1α.528 Consequently, the hypoxia signaling pathway may be one of the targets of treatment and illuminates the research on the treatment of other diseases caused by H. pylori. The gene discussed is HIF1A; the disease is duodenal ulcer.