Deubiquitinases (DUBs) can remove the ubiquitination of substrates, and the modulation of DUBs has now been identified as a promising drug target.470USP7, one of the DUB genes, induces tumors by stabilizing HIF-1α.471 However, USP7 inhibitors slowed the tumor development in Lewis LC mice.472. Here, HIF1A is linked to neoplasm.