CHST15 and myeloproliferative neoplasm: Our patients exhibited upregulated NPDC1 expression, suggesting the existence of signaling communication between CHST15 and NPDC1. When differentially expressed genes and proteins were integrated, we generated a signaling network related to the regulation of cell proliferation, differentiation, extracellular matrix formation and inflammatory responses associated with CHST15 mutation in familial MPN, which was conducive to our understanding of the molecular mechanism of CHST15 mutation-driven MPN.