In addition, overexpression of CHST15 may account for the prognosis of pancreatic cancer [29], invasive activity of breast cancer cells [30] and enhanced proliferation and sensitization to apoptosis of esophageal squamous cell carcinoma cells [31], suggesting the possibility that CHST15 is a functional oncogene. The gene discussed is CHST15; the disease is esophageal squamous cell carcinoma.