TARDBP and amyotrophic lateral sclerosis: Axonal transport deficits have also been observed in primary MN cultures from SOD1G93A [5] and TDP-43 [10] embryos, cultured SOD1G93A spinal cord explants [11], induced pluripotent stem cell (iPSC)-derived MNs harbouring ALS causative mutations in SOD1 [12], FUS [12] and TDP-43 [13], as well as in vivo, in transgenic TDP-43M337V mice [6].