Elevated levels of the endocannabinoid 2-arachidonoylglycerol (2-AG) upon pharmacological inhibition of the 2-AG-degrading enzyme monoacylglycerol lipase (MAGL) enhances OL development in cultured OPCs [11], both at embryonic stages in mice [10] and in the Theiler’s murine encephalomyelitis virus (TMEV) progressive mouse model of multiple sclerosis (MS) [12, 13]. This evidence concerns the gene MGLL and multiple sclerosis.