Cancer stem cells (CSCs) are thought to be responsible for tumor growth.[1] For example, CD133+ glioma cells form neurospheres, display multilineage differentiation capabilities in vitro, and are highly tumorigenic in the brains of immunocompromised mice.[2] Exploring the mechanism of the highly tumorigenic ability and therapy resistance of glioma stem cells (GSCs), contributes to a therapeutic approach for the treatment of brain tumors. This evidence concerns the gene PROM1 and central nervous system cancer.