Moreover, among 12 DEPs verified by MRM-MS analysis, three plasma proteins (CRP, C4A, and SAA4) were confirmed as potential independent biomarkers for the detection of HCA, which allowed to develop a two-marker panel (with AUC values of 0.899, comprising GNYDAAQR and VLSLAQEQVGGSPEK peptides of SAA4 and C4A, respectively) that could help improve the prediction of HCA. This evidence concerns the gene C4A and hepatocellular adenoma.