SAA4 and hepatocellular adenoma: Moreover, among 12 DEPs verified by MRM-MS analysis, three plasma proteins (CRP, C4A, and SAA4) were confirmed as potential independent biomarkers for the detection of HCA, which allowed to develop a two-marker panel (with AUC values of 0.899, comprising GNYDAAQR and VLSLAQEQVGGSPEK peptides of SAA4 and C4A, respectively) that could help improve the prediction of HCA.