CRP and hepatocellular adenoma: As observed in the targeted proteomics, the median plasma levels of CRP were significantly higher in women with HCA than in those without HCA (P < 0.001, Fig 4), and this difference remained significant even after adjusting for gestational age at sampling (odds ratio [OR]: 7.53; 95% CI: 1.10–51.34; P = 0.039) (S6 Table).