It is now evident that an endogenous FPR2 agonist such as LXA4 can stimulate another pro‐resolving mediator (e.g., ANXA1) in a feed‐forward resolution circuit; an example of this phenomenon is evident in the context of obesity‐induced liver and kidney disease (Borgeson et al., 2015) and in the inflamed mesenteric microvasculature (Brancaleone et al., 2011). Here, ANXA1 is linked to Obesity.