ANXA1 and obesity due to melanocortin 4 receptor deficiency: It is now evident that an endogenous FPR2 agonist such as LXA4 can stimulate another pro‐resolving mediator (e.g., ANXA1) in a feed‐forward resolution circuit; an example of this phenomenon is evident in the context of obesity‐induced liver and kidney disease (Borgeson et al., 2015) and in the inflamed mesenteric microvasculature (Brancaleone et al., 2011).