To verify the results of the trial study, we examined the levels of the 9 proteins, IGHV, GAPDH, C1s, GRP78, V-ATPase, PPBP, CD9, Lp(a) and SAP, in EVs isolated from the sera of another 80 patients with chronic hepatitis C before DAA treatment (S2 Table). The gene discussed is HSPA5; the disease is chronic hepatitis C virus infection.