BCKDK and obesity due to melanocortin 4 receptor deficiency: We next explored the relationship between BCKDK mRNA expression in hepatic tissue and the individual features of NASH, using liver biopsies from a smaller cohort of 60 bariatric surgery patients with severe obesity from the QHLI Obesity Biobank, as well as existing transcriptomics data from 107 bariatric surgery patients with severe obesity from the Mexican Obesity Surgery (MOBES) cohort (Supplemental Table 2).