These polarized Th cells release various chemotactic factors like IL-4, IL-5, IL-13, IL-17, and growth factors to promote eosinophil and neutrophil chemotaxis to the lung site and attributes various disease-associated factors including smooth muscle thickening, airway remodelling, airway constriction, fibrosis, and airway hyperresponsiveness (Davoine and Lacy 2014; Shastri et al. 2021; Zhu et al. 2020). This evidence concerns the gene IL5 and airway hyperresponsiveness.