Administration of oral, sublingual and oro-buccal THC and/or CBD at therapeutic doses for chronic pain, stress, anxiety, and insomnia provide plasma THC and CBD levels in the order of 1–10 ng/ml for THC, and 1–30 ng/mL for CBD (Britch et al. 2021; Crippa et al. 2021; Guy and Flint 2004; Henson et al. 2021; Millar et al. 2018; Prieto González and Vila Silván 2021; Silmore et al. 2021; Stott et al. 2013; Torres-Moreno et al. 2018; Vitetta et al. 2021). The gene discussed is OPN1MW; the disease is Anxiety.