OPN1MW and Euphoria: Although THC, the main component of cannabis responsible for euphoria and dependence, comprises 50% of the cannabinoids in equimolar THC and CBD oro-buccal sprays, dependence may be negligible with medicinal use of these products due to a higher level of CBD that antagonizes the psychotropic and anxiogenic activity of THC, lower peak plasma THC levels compared to smoking or vaping, steady state dosing, and users whose motivation is symptom relief without euphoria or cognitive changes (Robson 2011).