BDNF (brain-derived neurotropic factor) gene is one of the best-characterized protein-coding targets of REST, but there are also lincRNAs that are known to be directly regulated by REST and affected in HD brains: DGCR5 (DiGeorge syndrome critical region gene 5) and HAR1 (human accelerated region 1). This evidence concerns the gene DGCR5 and Huntington disease.