Another study carried out in circulating blood cells from 50 Iranian patients with RRMS, and 50 healthy controls showed downregulation of PVT1 (plasmacytoma variant translocation 1) with a moderate correlation between the level of expression of PVT1 and the duration of the disorder and no significant correlation with either the EDSS (expanded disability status scale) score or age at onset [22]. Here, PVT1 is linked to plasmacytoma.