To search for lincRNAs as biomarkers, in 2016, Santoro et al. screened 84 lncRNAs involved in autoimmunity and the human inflammatory response in serum from 12 patients with RRMS and 12 healthy controls and found lincRNAs that were upregulated in patients with RRMS and could play a role in neurodegenerative processes of MS, among others RN7SK RNA (the 7SK small nuclear RNA). Here, RN7SK is linked to relapsing-remitting multiple sclerosis.