TUG1 and relapsing-remitting multiple sclerosis: Intriguingly, studying PBMCs samples from 27 patients with RRMS, 13 patients with PPMS, and 31 healthy controls in the Italian population, Fenoglio et al. showed downregulation of TUG1 and identified a correlation between the TUG1 level and the EDSS score of the disease [19].