Therefore, LINC00507 indirectly regulates the levels of two genes involved in AD progression, MAPT (microtubule-associated protein tau), and TTBK1 (tau-tubulin kinase-1-encoding tau kinase), and eventually leading to enhanced Tau hyperphosphorylation by activating the p25/p35/Cdk5 and GSK3β signaling pathways (Table S1) [93]. Here, CDK5R1 is linked to Alzheimer disease.