KEGG pathway analysis revealed that lnc0640 and lnc5150 may participate in the development of SLE through the MAPK (mitogen-activated protein kinase) signaling pathway, which regulates the immune response of T and B cells as well as the production of multiple SLE-related inflammatory factors, such as TNF-α, IL-1/6, and IFN. This evidence concerns the gene IL1B and systemic lupus erythematosus.