Specific study of E230001N04Rik further confirmed the increased abundance of this lincRNA in AD cellular models and showed that E230001N04Rik can modulate the level of Tau by affecting the expression of its neighboring genes, Srpk1 (serine/arginine-rich splicing factor kinase 1) and Fkbp5 (FKBP prolyl isomerase 5), encoding for proteins involved in the production of Tau as well as its stability and aggregation, respectively. The gene discussed is MAPT; the disease is Alzheimer disease.