In turn, in mouse and cellular models of AD, Zhang et al. observed an elevated level of lincRNA H19 along with downregulated expression of miR-129 and upregulated expression of the miR-129 target, mRNA encoding the proinflammatory cytokine HMGB1 (high-mobility group box 1) (Table S1) [92]. The gene discussed is HMGB1; the disease is Alzheimer disease.