In this chapter, we focus on five lincRNAs with deregulated expression patterns in most of the disorders described, related both to autoimmune and neurodegenerative pathomechanisms: NEAT1 (MS, RA, SLE, SS, HD, PD, AD, ALS), MALAT1 (MS, RA, SLE, PD, AD, ALS), TUG1 (MS, RA, SLE, HD, PD, AD), MEG3 (MS, RA, HD, PD, AD), and XIST (MS, RA, HD, PD, AD). Here, XIST is linked to Alzheimer disease.