AKT1 and Alzheimer disease: MALAT1 has also been linked to the activation of the PI3K/AKT (phosphatidylinositol 3-kinase and serine/threonine protein kinase B) signaling pathway, as overexpression of MALAT1 or CNR1 in AD model cells resulted in increased phosphorylation of PIK3 and AKT [138].