In addition to blood pressure, blood lipids and exercise tests, molecular biomarkers such as circulating cardiac troponin T (cTnT) [15], N-terminal pro-B-type natriuretic peptide (NT-proBNP) [16] and growth-differentiation factor 15 (GDF-15) [17] are valuable tools in the diagnosis of preclinical heart disease. This evidence concerns the gene NPPB and heart disorder.