APLP2 and heart disorder: In the present study, the three markers from the fibrosome with the highest reported predictive values (APLP2, BNIP3L, CD59) (Laskaratos et al. 2020a) and an additional well-known fibrosis marker (DKK3) in renal (Lipphardt et al. 2019) and cardiac disease (Zeng et al. 2021; Zhai et al. 2018) were investigated on protein expression level in primary tumor samples.