This result is similar to the previous study by our group, where patients also showed downregulation of inflammatory markers, even with lower hyperglycemia.12 In another study with mice, supplementation with Eriodictiol, the aglycone form of Eriocitrin that is the main component of Eriomin, also showed inhibitory effects on the expression of IL-6 and TNF-α messenger RNA.22 The gene discussed is TNF; the disease is Hyperglycemia.