TRIM32 has been implicated in various neurological disorders, such as depression (Ruan et al., 2014), Alzheimer’s disease (Yokota et al., 2006), autism spectrum disorder (Lionel et al., 2014; Ruan et al., 2014), or attention deficit hyperactivity disorder (Lionel et al., 2011). Here, TRIM32 is linked to early-onset autosomal dominant Alzheimer disease.