As displayed in Figures 9(a) and 9(b), the expression of BiP in the mouse breast tissue stimulated by S. aureus was significantly reduced compared to the control group, while PDI, Ero1-Lα, p-IRE1α, PERK, and CHOP protein levels were restrained in the vitexin-treated mice with mastitis. The gene discussed is P4HB; the disease is mastitis.