Hitherto, the pathogenesis of hypertriglyceridemic pancreatitis is not very unclear; however, it is clear that high concentration of TG in serum can activate pancreatic lipase and produce a large amount of free fatty acids which may damage the capillaries and cell membrane of the pancreas; this process may release cytokines and inflammatory mediators, which can lead to pancreatitis [3]. The gene discussed is PNLIP; the disease is pancreatitis.