Clinical manifestations include acute disseminated encephalomyelitis (ADEM), optic neuritis that is often bilateral and/or severe, transverse myelitis that may be short segment or longitudinally extensive, unilateral cortical FLAIR-hyperintense lesions in anti-MOG-associated encephalitis with seizures (FLAMES) (4)/unilateral cerebral cortical encephalitis (UCCE) (5), and brainstem encephalitis (3, 6). Here, MOG is linked to optic neuritis.