As discussed above, the hub genes, including RSAD2, OASL, EPSTI1, CMPK2, IFIH1, IFIT5, USP18, MX1, and STAT1, might be closely related to intestinal inflammation and infection, which affected the intestinal morphology characterized by the obvious changes in villus height and width, and crypt depth (28–31). This evidence concerns the gene USP18 and infection.