In this study, 10 key genes of MS including HLA-DRA, HLA-DRB1, HLA-DRB5, HLA-DQB2, HLA-DPA1, HLA-DQB1, HLA-E, HLA-C, GBP2, and CD44 are obtained using the algorithm. This evidence concerns the gene HLA-DRA and myeloid sarcoma.