In this study, 10 key genes of MS including HLA-DRA, HLA-DRB1, HLA-DRB5, HLA-DQB2, HLA-DPA1, HLA-DQB1, HLA-E, HLA-C, GBP2, and CD44 are obtained using the algorithm. The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.