Furthermore, these results are consistent with known kinetics of humoral immune response against acute viral infections, in which extrafollicular short-lived plasmablasts contribute to early antibody production – IgM, IgG, IgA –, while a secondary increasing contribution of germinal centre-derived plasma cells – with longer lifespan and larger secretory capacity – leads to secretion of class-switched antibodies, mainly IgG. Here, CD40LG is linked to viral infectious disease.