Other advances regarding the diagnostic of PD have been observed, with Alpha-synuclein oligomers and small nerve fiber pathology in the skin as potential biomarkers, as well as analysis of presynaptic dopaminergic terminals and the severity of the putamen involvement through 99mTc-TRODAT-1 SPECT Imaging, presenting as potential diagnostic markers of PD (10, 11). This evidence concerns the gene SNCA and Parkinson disease.