Alterations in NMDAR function, CaMKIIα expression and dendritic spine anatomy in the hippocampus prevent LTP induction after lateral fluid percussion injury (Schwarzbach et al., 2006), thereby causing cognitive impairment often associated with CNS trauma (Atkins et al., 2006; Schwarzbach et al., 2006; Folkerts et al., 2007; Deshpande et al., 2008). Here, CAMK2A is linked to Cognitive impairment.