CAMK2G and Huntington disease: Being an abundant protein in striatal MSNs (Erondu and Kennedy, 1985), reduced levels of both CaMKII and CaMKII-Thr286 phosphorylation have been reported in various mouse models of HD (Deckel et al., 2001, 2002a,b; Brito et al., 2014; Blum et al., 2015; Gratuze et al., 2015).