In addition to NDDs and ID, CAMK2A variants/single nucleotide polymorphisms (SNPs)/single nucleotide variants (SNVs) have been reported to be associated with risk for bipolar disorder (BD) in cohorts of European descent (Ament et al., 2015), in sporadic AD patients belonging to the Han Chinese population (Fang et al., 2019) and mild cognitive impairment (MCI) subjects in a Spanish population (Bufill et al., 2015). The gene discussed is CAMK2A; the disease is Cognitive impairment.