CaMKII activation dependent on NMDARs or L-type VGCCs can also phosphorylate serine residues of GluR6 subunit of kainate receptors via the assembly of GluR6-PSD95-CaMKII signaling module in cerebral ischemia injury (Hao et al., 2005; Xu et al., 2010). This evidence concerns the gene GRIK2 and brain ischemia.