CAMK2G and Mental deterioration: Loss of synapses and cognitive decline associated with AD positively correlate to the accumulation of soluble Aβ (Lue et al., 1999; Näslund et al., 2000; Almeida et al., 2005), which leads to reduced CaMKII activation (Zeng et al., 2010; Ly and Song, 2011; Ghosh and Giese, 2015) and inhibition of LTP-induced CaMKII trafficking to excitatory synapses (Cook et al., 2019).