Indeed, as compared to 5-HT2C receptors, several studies have reported that 5-HT2B agonists rather than antagonists display anxiolytic actions.48,70,96,97 Accordingly, there is no evidence for a role of 5-HT2B blockade in the influence of agomelatine upon anxiety, and the discussion below focusses on 5-HT2C receptors. Here, HTR2B is linked to Anxiety.