However, while there is increasing evidence for the relevance of heteromeric G-protein-coupled receptor (GPCR) complexes to central nervous sytem (CNS) disorders,146,147 it is not yet known whether 5-HT2C-MT2 heterodimers are affected in the brain of GAD patients, nor whether their activity is altered under conditions of stress. The gene discussed is HTR2C; the disease is generalized anxiety disorder.