HTR2C and Anxiety: Agomelatine would act oppositely to SSRIs in blocking BNST-located 5-HT2C sites and moderating CRF output, contributing to the expression of its anxiolytic properties in the absence of an early phase of aggravated anxiety.2,13,28,121 CRF may not be the only neuropeptide potentially implicated in the actions of agomelatine.